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Eff ect of point mutations in the INK4A/ARF locus on ARF-mediated autophagy in tumor cells

Soloviev Alexander   (Doctor of medical Sciences, Professor, Smolensk state medical University)

Budina Anna   (PhD, research Intern, Wistar Institute, Philadelphia, USA)

Anaschenkova Tatiana   (PhD, associate Professor, Smolensk state medical University)

The article presents data on the effect of tumor-derived point mutations in the INK4a/ARF locus on ARF-mediated autophagy in human tumor cells. In experiments on cells of an osteosarcoma is shown that a point mutations of the gene ARF, located in a plot of activation of autophagy, impair the ability of tumor suppressor ARF to induce autophagy in tumor cells.

Keywords:autophagy, tumor suppressor, ARF, point mutations.
 

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Citation link:
Soloviev A. , Budina A. , Anaschenkova T. Eff ect of point mutations in the INK4A/ARF locus on ARF-mediated autophagy in tumor cells // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2019. -№06. -С. 35-39
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