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THE EFFECT OF SMOKING ON THE CONTENT OF α2- AND γ-GLOBULIN FRACTIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Agapova Yulia Rеfatovna  (Candidate of Medical Sciences, Associate Professor of the Department of Physics and BMT, Lipetsk State Technical University )

Strokovsky Grigory Semyonovich  (Candidate of Technical Sciences, Associate Professor of the Department of Physics and BMT, Lipetsk State Technical University )

Nazarova Victoria Alvidovna  (Senior Lecturer of the Department of Physics and BMT, Lipetsk State Technical University )

Chronic obstructive pulmonary disease (COPD), being a chronic inflammatory disease, is reflected during the period of exacerbation in the content of protein fractions in the blood serum of patients. An increase in the level of the α2-globulin fraction is a positive marker of serum antiprotease activity as a protective reaction of the body to the action of tissue-damaging proteases at the height of inflammation. A decrease in the content of the gamma-globulin fraction in the late stages of COPD is a consequence of depletion of immunity against the background of a chronic inflammatory process. To prove the importance of antismoking measures, an assessment of the effect of smoking on the content of α2- and γ-globulin fractions and on the life prognosis in patients with exacerbation of COPD depending on smoking/non-smoking was carried out.

Keywords:chronic obstructive pulmonary disease, serum protein fractions, α2-globulins, γ-globulins, antiprotease activity, immunoglobulin deficiency.

 

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Citation link:
Agapova Y. R., Strokovsky G. S., Nazarova V. A. THE EFFECT OF SMOKING ON THE CONTENT OF α2- AND γ-GLOBULIN FRACTIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№09. -С. 126-132 DOI 10.37882/2223-2966.2024.9.01
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