Kotelnikova Nadezhda (Applicant for the Department of Ultrasound Diagnostics, IPO SamSMU
Samara State Medical University
Russian Federation, Samara
)
Balter Regina (Candidate of Medical Sciences, Professor
Head of the Department of Ultrasound Diagnostics, IPO SamSMU
Samara State Medical University
Russian Federation, Samara
)
Tselkovich Lyudmila (Doctor of Medical Sciences
Professor of the Department of Ultrasound Diagnostics, IPO SamSMU
Samara State Medical University
Russian Federation, Samara
)
Ivanova Tatiana (Candidate of Medical Sciences
Associate Professor, Department of Ultrasound Diagnostics, IPO SamSMU
Samara State Medical University
Russian Federation, Samara
)
Podgornyaya Milla (Applicant for the Department of Ultrasound Diagnostics, IPO SamSMU
Samara State Medical University
Russian Federation, Samara
)
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The features of changes in IHC parameters, including estrogen, progesterone, Ki67, P53, and E-cadregin receptors, markers reflecting the features of cellular apoptosis and proliferation, in a group of women of reproductive age with endometrial hyperplasia in the presence of atypia, as well as without it, are considered. It was found that the expression of estrogen and progesterone receptors in patients with hyperplasia is lower than in women with normal endometrium. It was determined that in endometrial hyperplasia there is local hyperestrogenism, manifested by an increase in ER-α/PR-A: in hyperplasia without atypia, the expression of estrogen receptors increases in the glands, in atypical hyperplasia – in the stromal component of the endometrium. It was found that cellular proliferative activity was most pronounced in the glands of women with atypical hyperplasia, while the activity of apoptosis, determined by the expression of p53, in the glands of these patients was the least.
Keywords:immunohistochemistry, estrogen receptors, progesterone receptors, Ki67, P53, e-cadregin, endometrial hyperplasia
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Citation link:
Kotelnikova N. , Balter R. , Tselkovich L. , Ivanova T. , Podgornyaya M. FEATURES OF ENDOMETRIAL RECEPTION IN WOMEN OF REPRODUCTIVE AGE WITH ENDOMETRIAL HYPERPLASIA (IMMUNOHISTOCHEMICAL STUDY) // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№11/2. -С. 178-185 DOI 10.37882/2223-2966.2024.11-2.18 |
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