Arsakhanova Gayna Abdullovna (FGBOU VO "Chechen State University named after. A.A.Kadyrova"
PhD, Associate Professor, Head of the Department of Histology and Pathological Anatomy
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Relevance. Chronic hypoxia is a key factor in the development of a wide range of cardiovascular diseases, however, the ultrastructural foundations of cardioadaptation to oxygen deficiency remain poorly understood. The aim of the work is to identify the peculiarities of transformation of intracellular organelles of cardiomyocytes under prolonged hypoxic exposure. Methods. The study was conducted on 40 mongrel white male rats divided into control (n=20) and experimental (n=20) groups. Modeling of chronic hypoxia was carried out by keeping animals in conditions of hypobaric hypoxia (GBH) with an "ascent" to an altitude of 5000 m above sea level for 6 hours daily for 45 days. The left ventricular myocardium samples were examined by light and electron microscopy. Results. It has been established that chronic HBH induces a complex of compensatory and adaptive changes in cardiomyocytes: 1) an increase in the specific volume of mitochondria with an increase in the number and size of crysts; 2) hypertrophy and polymorphism of nuclei with a predominance of euchromatin; 3) the formation of an extensive network of sarcoplasmic reticulum and Golgi complex. Discussion. Prolonged adaptation to hypoxia activates intracellular mechanisms of energy production and protein synthesis in cardiomyocytes, which ensures the maintenance of contractile function in conditions of oxygen starvation. The obtained data deepen the understanding of the cellular and molecular foundations of cardioadaptation and open up prospects for the development of new approaches to the prevention and treatment of hypoxic myocardial conditions.
Keywords:hypoxia, ultrastructure, cardiomyocytes, adaptation, mitochondria, sarcoplasmic reticulum
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Citation link:
Arsakhanova G. A. THE EFFECT OF PROLONGED HYPOXIC EXPOSURE ON THE ULTRASTRUCTURAL ORGANIZATION OF CARDIOMYOCYTES // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№11. -С. 188-193 DOI 10.37882/2223-2966.2024.11.02 |
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