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ASSOCIATION OF GENES FOR DETOXIFICATION OF XENOBIOTICS GSTT1 AND GSTM1 WITH MISCARRIAGE IN WOMEN OF SHOR NATIONALITY OF THE KEMEROVO REGION – KUZBASS

Luzina Faina Anisimovna  (Ph.D. in biological sciences Leading researcher of the molecular-genetic and experimental study laboratory Research Institute for Complex Problems of Hygiene and Occupational Diseases Russia, Novokuznetsk )

Doroshilova Anastasia Viktorovna  (Applicant of the Research Institute for Complex Problems of Hygiene and Occupational Diseases Russia, Novokuznetsk )

Palevskaya Svetlana Alexandrovna  (MD, PhD, director-vice-rector for regional health development Institute of professional education Samara State Medical University Russia, Samara )

Zhukova Anna Gennadievna  (Dr. Sci. Biol. Head of the molecular-genetic and experimental study laboratory Research Institute for Complex Problems of Hygiene and Occupational Diseases Russia, Novokuznetsk )

Gulyaeva Olga Nikolaevna  (Senior researcher of the molecular-genetic and experimental study laboratory Research Institute for Complex Problems of Hygiene and Occupational Diseases Russia, Novokuznetsk )

Kazitskaya Anastasiya Sergeevna  (Ph.D. in biological sciences Leading researcher of the molecular-genetic and experimental study laboratory Research Institute for Complex Problems of Hygiene and Occupational Diseases Russia, Novokuznetsk )

Yadykina Tatyana Konstantinovna  (Ph.D. in biological sciences Leading researcher of the molecular-genetic and experimental study laboratory Research Institute for Complex Problems of Hygiene and Occupational Diseases Russia, Novokuznetsk )

Ivanova Tatiana Vladimirovna  (Candidate of medical sciences Associate Professor, Department of Ultrasound Diagnostics, IPO SamSMU Samara State Medical University Russia, Samara )

Ilchenko Olesya Andreevna  (Ph.D., assistant of the Department of Ultrasound Diagnostics IPO SamSMU Samara State Medical University Russia, Samara )

The associations of polymorphic variants of GSTM1 and GSTT1 genes and their combinations with miscarriage of pregnancy in women of the Shor nationality of the Kemerovo region were studied, and the possible genetic risk was calculated. In expedition conditions 151 women were examined, 64 of them with miscarriage of pregnancy. The polymorphisms of GSTM1 and GSTT1 genes were typed by Real Time PCR method. A positive association between the GSTM1 gene and the risk of pregnancy failure was revealed. It was found that the protective effect is associated with the combination of “functionally active” genotypes GSTM1 + / GSTT1 +.

Keywords:Shors, xenobiotic biotransformation genes GSTM1 and GSTT1, miscarriage.
 

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Citation link:
Luzina F. A., Doroshilova A. V., Palevskaya S. A., Zhukova A. G., Gulyaeva O. N., Kazitskaya A. S., Yadykina T. K., Ivanova T. V., Ilchenko O. A. ASSOCIATION OF GENES FOR DETOXIFICATION OF XENOBIOTICS GSTT1 AND GSTM1 WITH MISCARRIAGE IN WOMEN OF SHOR NATIONALITY OF THE KEMEROVO REGION – KUZBASS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№11. -С. 218-225 DOI 10.37882/2223-2966.2024.11.19
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