Sultanova Oksana Esedullayevna (Candidate of Medical Sciences
аssistant of the Department of Cardiology
Astrakhan State Medical University
Ministry of Health of Russia
)
Chernysheva Elena Nikolaevna (Doctor of Medical Sciences,
Head of the Department of Cardiology
Astrakhan State Medical University
Ministry of Health of Russia
)
Khatamova Enejan Azizovna (Resident of the Department of Cardiology of the FPO
Federal State Budgetary Educational
Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
Kadirov Izzat Khamrakulyevich (Resident of the Department of Cardiology of the FPO
Federal State Budgetary Educational
Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
Butsukina Olesya Nikolaevna (Resident of the Department of Cardiology of the FPO
Federal State Budgetary Educational
Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
Akhmedpashaev Gadzhi Tagirovich (Resident of the Department of Cardiology of the FPO
Federal State Budgetary Educational
Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
Rasulzade Arzu Gazanfarkyzy (Resident of the Department of Cardiology of the FPO
Federal State Budgetary Educational Institution
institution of higher education
Astrakhan State Medical University
Ministry of Health of the Russian Federation
)
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The leading positions in mortality and disability both in the Russian Federation and abroad are occupied by the pathology of the cardiovascular system. It is important to note that cardiovascular diseases often develop against the background of genetic factors, such as undifferentiated connective tissue dysplasia. There is also a close relationship between cardiovascular diseases on the background of undifferentiated connective tissue dysplasia and mental disorders, especially affective, such as anxiety and depression. The article investigates the relationship of the level of oxyproline (as a marker of dysplasia) on psychological features of patients with acute coronary syndrome against the background of undifferentiated connective tissue dysplasia.
Based on a careful selection of 528 patients, 220 patients with ACS were included in the study, of whom 113 had SNDST. The groups were comparable by age and sex.
Methods of research: physical, laboratory, instrumental, special methods of research (immunoenzymatic analysis to determine the level of the following parameters: to confirm undifferentiated connective tissue dysplasias the level of human antibodies to collagens of type II and III - oxyproline (OR) was determined), determination of Mg concentration in blood serum was carried out according to the standard technique specified in the Simco Mg determination kit.
Diagnosis of undifferentiated connective tissue dysplasia was carried out on the basis of questionnaire according to Elykomov V.A. and Kopylov A.N. (detection of 6 or more stigmas of dysembryogenesis).
The following programs were used for statistical analysis of the obtained data: IBM SPSS Statistics 28 and StatTech v. 3.1.8.
In the course of the study we studied and analyzed: level of OR, determined the incidence of depression syndrome in patients of the studied groups and obtained the following results - the level of OR in patients with ACS on the background of undifferentiated connective tissue dysplasia is statistically significantly higher than in patients with ACS without undifferentiated connective tissue dysplasia and amounted to 48.6 [46.7; 59.3] μmol/l; the incidence of depression in patients with ACS and undifferentiated connective tissue dysplasia amounted to 72%, in the group of patients with ACS - 39%. The same proved the correlation between the level of oxyproline and depression in patients with ACS on the background of undifferentiated connective tissue dysplasia. When estimating the level of OR in patients with depression the results were obtained - in the group of depressed patients with ACS with undifferentiated connective tissue dysplasia the level of OR was 48.6 [46.7; 59.3] μmol/l, which is statistically significantly higher compared to the group of patients with ACS without undifferentiated connective tissue dysplasia (p<0.001). We have established the following pattern, the higher the level of OR and, accordingly, the lower the magnesium level and, as a consequence, the high risk of depressive disorders in patients.
Keywords:acute coronary syndrome, undifferentiated connective tissue dysplasia, oxyproline, psychological characteristics, depression
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Citation link: Sultanova O. E., Chernysheva E. N., Khatamova E. A., Kadirov I. K., Butsukina O. N., Akhmedpashaev G. T., Rasulzade A. G. THE RELATIONSHIP BETWEEN OXYPROLINE LEVELS AND DEPRESSION IN PATIENTS WITH ACUTE CORONARY SYNDROME ON THE BACKGROUND UNDIFFERENTIATED DYSPLASIA CONNECTIVE TISSUE // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№12. -С. 235-240 DOI 10.37882/2223-2966.2024.12.33 |
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