Berdysh Denis Sergeevich (Assistant of the Department of Functional Disciplines
Non-profit educational private institution of higher education
"Kuban Medical Institute"
Krasnodar city. Russian Federation.
)
Aceh Tamara Varzamesovna (Candidate of Medical Sciences, Associate Professor
FGBOU "MSTU"
Maykop. Russian Federation.
)
Likh Dmitry Pavlovich (Non-profit educational private institution of higher education
"Kuban Medical Institute"
)
Beslangurova Zarema Aslanovna (Candidate of Medical Sciences, Associate Professor.
Dean of the Faculty of Medicine
Federal State Budgetary Institution of Higher Education
"Maikop State Technological University"
Krasnodar. Russian Federation.
)
Ilchenko Galina Vladimirovn (Candidate of Historical Sciences, Associate Professor.
Head of the Department of Social and Humanitarian Disciplines
Non-profit educational private institution of higher education
"Kuban Medical Institute"
Krasnodar. Russian Federation.
)
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Antiphospholipid syndrome (AFS) is a common autoimmune disease caused by AT, which cause the membranes of various cells of the body to alter. In modern concepts, AFS is a widespread non—inflammatory immune process based on the formation of bimodal autoantibodies in the human body in a high titer interacting with negatively charged plasma phospholipid membranes and associated proteins — glycoproteins. The main targets of AFA are negatively charged cardiolipin, phosphatidylserine, phosphatidylethanolamine, phosphatidylic acid, and of the protein components — β2glycoprotein I, annexin V and prothrombin. It is also important that most studies on (ATA) Antiphospholipid antibodies are found in 2-4% of healthy people in the circulating blood, but in women (ATA) in the blood 2-5 times more often than in men.
The purpose of the study: data analysis and identification of patterns of development of the nephrogenic form of antiphospholipid syndrome. The presence of antiphospholipid antibodies can be clinically manifested by severe kidney damage, such as thrombosis of large renal vessels, renal artery stenosis and intrarenal lesions, which lead to antiphospholipid nephropathy.
The course of the disease can range from slowly progressive nephropathy to life-threatening acute renal failure. This condition is associated with acute antibody-associated thrombotic microangiopathy of varying severity, proliferative and fibrous vascular changes. Secondary antiphospholipid syndrome in association with systemic lupus erythematosus is the most studied and widely known. At the same time, isolated antiphospholipid nephropathy remains poorly understood and requires further deeper, detailed and radical research methods. The study of the pathogenetic mechanisms of antiphospholipid syndrome has long been focused on blood clotting factors, endothelial cells and platelets. And only a few studies in recent years have shed light on additional potential therapeutic targets within the innate immune system, including the complement system and extracellular neutrophil traps. Evidence base of medicinal products etiotr.
Keywords:AFS, nephropathy, kidneys, thrombosis, blood vessels, systemic nature, complications, treatment, antiphospholipid antibody, KAFS
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Citation link:
Berdysh D. S., Aceh T. V., Likh D. P., Beslangurova Z. A., Ilchenko G. V. THE NEPHROGENIC FORM OF ANTIPHOSPHOLIPID SYNDROME. // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2024. -№12. -С. 167-172 DOI 10.37882/2223-2966.2024.12.07 |
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