Gubanov Dmitry Sergeevich (Senior lecturer
Place of work: FSBI HE “TSU named after G.R. Derzhavin”, Institute of medicine and health preservation , the Department of propaedeutics of internal diseases and faculty therapy
)
Gubanova Kseniya Mikhailovna (assistant teacher,
Tambov State University named after G.R. Derzhavin, Institute of medicine and health preservation, the Department of hospital therapy
)
Rebrov Dmitry Stanislavovich (Tambov State University named after G.R. Derzhavin)
Konchakova Elizaveta Andreevna (Tambov State University named after G.R. Derzhavin)
Tolstykh Anton Alekseevich (Tambov State University named after G.R. Derzhavin)
| |
In clinical practice, general practitioners often encounter patients with bone lesions, particularly in elderly populations. This creates a need for differential diagnosis, especially with multiple myeloma, a condition frequently accompanied by bone damage. This article discusses a clinical case involving a patient with myeloma exhibiting a predominantly osteodestructive progression. A key aspect of studying hematological or oncological diseases lies in understanding their progression at the cellular level. Such insights are critical for identifying diagnostic markers and determining therapeutic targets. Accordingly, the second part of the study explores the pathophysiological mechanisms underlying the pathogenesis of this disease.
Objective: To examine the clinical manifestations, diagnostic approaches, and progression of osteodestructive lesions in multiple myeloma.
Relevance: Multiple myeloma is a disease characterized by a diverse pathological profile, primarily affecting elderly patients. One of its most common manifestations is osteodestructive lesions. Therefore, understanding the disease's pathogenesis is essential for differential diagnosis, given the high prevalence of primary bone lesions in older adults.
Keywords:Multiple Myeloma, Osteoblasts, Osteoclasts, RANKL, Wnt Signaling Pathway, Monoclonal Gammopathy, Bone Remodeling
|
|
| |
|
Read the full article …
|
Citation link:
Gubanov D. S., Gubanova K. M., Rebrov D. S., Konchakova E. A., Tolstykh A. A. CLINICAL CASE: DEVELOPMENT OF OSTEODESTRUCTIVE LESIONS IN THE CONTEXT OF MULTIPLE MYELOMA // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№01. -С. 182-189 DOI 10.37882/2223-2966.2025.01.14 |
|
|
