Useinova Rean Khairievna (Assistant, Department of Internal Medicine No. 2,
V.I. Vernadsky Crimean Federal University, Order of Red Banner of Labor S. I. Georgievsky Medical Institute, Simferopol, Russia
)
Beloglazov Vladimir Alekseevich (Doctor of Medical Sciences, Professor,
Head of the Department, Internal Medicine No. 2,
V.I. Vernadsky Crimean Federal University, Order of Red Banner of Labor S. I. Georgievsky Medical Institute, Simferopol, Russia
)
Yatskov Igor Anatolievich (PhD, Associate Professor, Internal Medicine Department No. 2,
Vernadsky Crimean Federal University, Order of Labor Red Banner Medical Institute named after S. I. Georgievsky, Russia, Simferopol, Crimea
)
Repinskaya Irina Nikolaevna (Assistant, Department of Internal Medicine No. 2,
Vernadsky Crimean Federal University, Order of Labor Red Banner Medical Institute named after S. I. Georgievsky, Russia, Simferopol, Crimea
)
Pentkovskaya Donata Alexandrovna (Vernadsky Crimean Federal University, Order of Labor Red Banner Medical Institute named after S. I. Georgievsky, Russia, Simferopol, Crimea)
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The aim of the work was to study the concentration of lipopolysaccharide-binding protein (LBP) as the main marker of endotoxin-binding systems in patients with DM1 and hypertension. Objectives: to search for potential relationships between the risk of hypertension and the level of LBP, to study the role of LBP in the development of hypertension in the group of patients with DM1, to determine the significance of the relationship between LBP and the risk of hypertension, and to search for possible links in the regulation of lipopolysaccharide-binding systems in patients with DM1. The hypothesis of the study: LBP may be a potentially significant marker of the risk of hypertension, which in the future may become the point of application of personalized therapy. Methods. The study included 92 patients with a diagnosis of DM1. According to medical records, 32 patients had hypertension. The patients underwent an enzyme immunoassay (ELISA) blood plasma test to determine the level of LBP (ng/ml). Results. The area under the ROC curve corresponding to the relationship between the prognosis of hypertension and the level of LDL in peripheral blood was 0.706±0.061 with 95% CI: 0.586-0.826, p=0.004. When the concentration of LBP was equal to or greater than 5.75 ng/ml, a low risk of hypertension was predicted.
Keywords:diabetes mellitus, lipopolysaccharide-binding protein, arterial hypertension.
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Citation link:
Useinova R. K., Beloglazov V. A., Yatskov I. A., Repinskaya I. N., Pentkovskaya D. A. LIPOPOLYSACCHARIDE-BINDING PROTEIN AND ARTERIAL HYPERTENSION IN PATIENTS WITH TYPE 1 DIABETES MELLITUS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№04. -С. 260-265 DOI 10.37882/2223-2966.2025.04.43 |
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