Matsaeva Olga Dmitrievna (Intern researcher of the Department of Biology and General Genetics
First Moscow State Medical University I.M. Sechenov
(Sechenov University)
)
Grinev Alexander Borisovich (PhD, associate professor of the Department of Biology and General Genetics
First Moscow State Medical University I.M. Sechenov
(Sechenov University)
)
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Malaria remains a global health concern, exacerbated by parasite resistance and diagnostic challenges in the context of antimalarial drug use. This review consolidates data on the mechanisms of action of key antimalarial agents and their impact on Plasmodium morphology.
The study underscores that drug-induced morphological alterations (e.g., cytoplasmic degradation, pigment accumulation) significantly complicate microscopy-based diagnosis. Such changes elevate the risk of pathogen species misidentification, particularly critical in low-endemic regions and imported malaria cases. The work further highlights the imperative for implementing molecular-genetic diagnostic approaches (PCR, LAMP) to mitigate human error and enhance diagnostic accuracy.
Keywords:malaria, anti-Infective agents, diagnosis, morphology.
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Read the full article …
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Citation link:
Matsaeva O. D., Grinev A. B. EFFECT OF ANTIMALARIAL DRUGS ON THE MORPHOLOGY OF PARASITES OF THE GENUS PLASMODIUM // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№06/2. -С. 41-44 DOI 10.37882/2223-2966.2025.06-2.22 |
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