Sheyko E. A. (Associate Professor of the Department of Microbiology, Virology and Immunology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky; V.I. Vernadsky Crimean Federal University; Simferopol)
Sytnikov D. M. (Associate Professor of Fundamental Medicine, Healthcare and Health Preservation Department, Institute of Fundamental Medicine and Health Saving, Sevastopol State University; Sevastopol)
Shihaleva O. K. (Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky; V.I. Vernadsky Crimean Federal University; Simferopol)
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There has been a resurgence of interest in the development of bacterial-based biotherapies for cancer in the last decade which is linked to advances in genetic engineering and a deep understanding of the mechanisms of infection and immunity. Cancer bacterial therapy can be used both as a monotherapy and in combination with other anti-cancer treatments to achieve the best clinical results. The purpose of this review is to consider the current status and prospects for the development and use of live pathogenic bacteria drugs for malignant tumors. The review presents data on the evaluation of experimental models of antitumor potential of different species and strains of bacteria; the most significant results of clinical trials of bacterial antitumor agents; modern directions of the construction of bacterial strains as means for targeted delivery of drug substances into tumors. We also discuss how various pathogenic bacteria have been modified with genetic engineering to develop the ability to cause tumor regression, and prospects for bacterial antitumor therapy. It was concluded that the development of bacterial agents for cancer therapy is a promising area of experimental oncology.
Keywords:oncological diseases; bacterial therapy; bacteriotherapy; bacteria targeting the tumor; cancer immunotherapy; therapeutic bacteria
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Citation link:
Sheyko E. A., Sytnikov D. M., Shihaleva O. K. PATHOGENIC BACTERIA IN ANTITUMOR THERAPY // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2025. -№07. -С. 36-40 DOI 10.37882/2223-2966.2025.07.40 |
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