Sultanova Oksana Esedullayevna (кандидат медицинских наук, доцент
Федерального государственного бюджетного образовательного
учреждения высшего образования
«Астраханский государственный медицинский университет»
Министерства здравоохранения Российской Федерации
)
Chernysheva Elena Nikolaevna (Doctor of Medical Sciences,
Astrakhan State Medical University
Ministry of Health of Russia
)
Djaalali Wail (Resident
Astrakhan State Medical University
Ministry of Health of Russia
)
Naamun Dallel (Resident
Astrakhan State Medical University
Ministry of Health of Russia
)
Trabelsi Shaima (Resident
Astrakhan State Medical University
Ministry of Health of Russia
)
Herbi Salman (Resident
Astrakhan State Medical University
Ministry of Health of Russia
)
Ruis Hawa Johar (Resident
Federal State Budgetary Educational Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
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Relevance: Cardiovascular diseases (CVD) are one of the leading causes of mortality worldwide, accounting for approximately one-third of all deaths, according to the World Health Organization. In Russia, in 2024, there were 1,542,300 cases of CVD in patients with syndromic nonspecific connective tissue dysplasia (SNDCT). The prevalence of depression in patients with a confirmed diagnosis of SNDCT reached 48.5%. Aim of the study: To develop an management algorithm for patients with CVD on the background of SNDCT and concomitant depressive disorders. Materials and methods: This was a prospective, multicenter study involving 150 patients aged 40–65 years, conducted at the S.M. Kirov City Clinical Hospital No. 3 in Astrakhan from 2019 to 2025. The examination included clinical, laboratory, and instrumental investigations, with diagnosis of SNDCT based on standard guidelines (questionnaires by Yelikonov and Kopylov, detection of collagen antibodies by ELISA, and levels of hydroxyproline). Depression assessment was performed using the Beck and Hamilton scales. Results: Significant patterns were identified: women are more prone to depression, with the peak incidence at 40–50 years; high body mass index and low physical activity exacerbate depressive symptoms; the presence of endocrine disorders (such as diabetes mellitus and hypothyroidism) increases the risk of depression; the duration of the primary disease correlated with anxiety and lowered mood; socioeconomic difficulties worsened emotional well-being. Conclusion: The implementation of the developed algorithm in clinical practice contributed to improved quality of life and reduced risks of complications in patients with CVD on the background of SNDCT and depression.
Keywords:acute coronary syndrome, connective tissue dysplasia, cardiovascular diseases, psycho-emotional disorders, depression
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Read the full article …
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Citation link:
Sultanova O. E., Chernysheva E. N., Djaalali W. , Naamun D. , Trabelsi S. , Herbi S. , Ruis H. J. MANAGEMENT ALGORITHM FOR PATIENTS WITH CARDIOVASCULAR DISEASES ASSOCIATED WITH CONNECTIVE TISSUE DYSPLASIA AND CONCOMITANT DEPRESSIVE DISORDERS // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2026. -№01. -С. 205-210 DOI 10.37882/2223-2966.2026.01.31 |
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