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THE EFFECT OF MELATONIN ON FEMALE REPRODUCTIVE FUNCTION (LITERATURE REVIEW)

Ichmelyan Albert Misakovich  (Candidate of Medical Sciences, Associate Professor Ulyanovsk State University )

Bogdasarov Azat Yuryevich  (MD, Professor Ulyanovsk State University )

Davidyan Liana Yuryevna  (MD, Professor Ulyanovsk State University )

This literature review demonstrates that melatonin has a multifaceted effect on reproductive function. In the ovaries, it modulates steroidogenesis, suppresses oxidative stress and apoptosis in oocytes and granulosa cells, improves mitochondrial function, and slows ovarian aging. In the endometrium, melatonin, acting through its receptors, regulates stromal cell proliferation and apoptosis and improves receptivity by modulating the expression of key implantation markers. Its effect on suppressing myometrial contractility has been demonstrated. Particular attention is given to the use of melatonin in assisted reproductive technologies, where its addition to culture media and prior administration by patients improves oocyte quality, fertilization, and embryo morphology.

Keywords:melatonin, reproductive function, fertility, oxidative stress, oocytes, endometrium, assisted reproductive technologies (ART), circadian rhythms.
 

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Citation link:
Ichmelyan A. M., Bogdasarov A. Y., Davidyan L. Y. THE EFFECT OF MELATONIN ON FEMALE REPRODUCTIVE FUNCTION (LITERATURE REVIEW) // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2026. -№01. -С. 199-204 DOI 10.37882/2223-2966.2026.01.17
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