Sultanova Oksana Esedullayevna (Candidate of Medical Sciences,
Docent
Federal State Budgetary Educational Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of Russia
)
Chernysheva Elena Nikolaevna (Doctor of Medical Sciences,
Federal State Budgetary Educational Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of Russia
)
Prokopenko Nadezhda Andreyevna (Candidate of Medical Sciences,
Docent
Federal State Budgetary Educational Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
Khojha Shuruk (Residen
Federal State Budgetary Educational Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
Manal Sheddiura (Resident
Federal State Budgetary Educational Institution of Higher Education
"Astrakhan State Medical University"
Ministry of Health of the Russian Federation
)
| |
Research Objective: to study the gender-specific features of homocysteine influence on the risk of developing acute coronary syndrome (ACS) in patients with undifferentiated connective tissue dysplasia (UCTD). Materials and Methods: a prospective cohort study was conducted, including men and women diagnosed with connective tissue dysplasia and at high risk of developing ACS. The study took place at PSO GKB No. 3 named after S.M. Kirov during 2019–2025. A total of 150 patients aged 40 to 65 years, with elevated risk factors for ACS against the background of UCTD, were examined. All patients underwent clinical, laboratory, and instrumental investigations. Diagnosis of UCTD was based on clinical guidelines: the clinical assessment included a questionnaire by V.A. Yelykomov and A.N. Kopylov; for confirmation, the presence of antibodies to collagens II and III was determined using ELISA (Oxtoproline [OP]). Homocysteine (Hcy) levels in plasma samples were measured via enzyme-linked immunosorbent assay (ELISA). Statistical analysis of the results was performed using IBM SPSS Statistics 28.0 software. Results: the study confirmed significant gender differences in homocysteine levels among the examined groups and revealed a close correlation between elevated homocysteine levels and increased risk of acute coronary events in patients with connective tissue dysplasia. Conclusion: it was established that men have significantly higher homocysteine concentrations and a greater risk of developing ACS compared to women, highlighting the need for an individualized approach to prevention and treatment. Additionally, the study developed recommendations for managing patients with UCTD and the risk of ACS.
Keywords:connective tissue dysplasia, acute coronary events, gender characteristics, homocysteine
|
|
| |
|
Read the full article …
|
Citation link:
Sultanova O. E., Chernysheva E. N., Prokopenko N. A., Khojha S. , Manal S. GENDER-SPECIFIC EFFECTS OF HOMOCYSTEINE ON THE RISK OF ACUTE CORONARY SYNDROME IN PATIENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME // Современная наука: актуальные проблемы теории и практики. Серия: Естественные и Технические Науки. -2026. -№01. -С. 211-215 DOI 10.37882/2223-2966.2026.01.32 |
|
|
